Russian second seed Daniil Medvedev and Alexander Zverev are additionally in motion, whereas Victoria Azarenka shall be trying to prolong her finest Roland Garros run since 2015.
The 39-year-old Williams noticed yet one more of her potential title rivals exit the match on Thursday, as world primary Ashleigh Barty hobbled out in the course of the second spherical with a hip harm.
After Naomi Osaka’s shock withdrawal, Simona Halep failing to start out the match by harm and early losses for Bianca Andreescu and Angelique Kerber, not one of the gamers who’ve overwhelmed Williams in Grand Slam finals since her final title within the 2017 Australian Open are nonetheless within the competitors.
The previous world primary, nonetheless only one in need of Margaret Court docket’s all-time file of main trophies, faces fellow American Danielle Collins for a spot within the final 16.
Serena + Tsitsipas + Sabalenka Day 6 has the products. Extra on the Friday storylines to observe at #RolandGarros.👇
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Williams received her solely earlier assembly with Collins, a Roland Garros quarter-finalist final 12 months and 2019 Australian Open semi-finalist, in Melbourne earlier this 12 months.
She says the pair hit it off off the courtroom, nevertheless it’s unlikely the three-time French Open winner will take it simple on her pal on Court docket Philippe Chatrier.
“She (Collins) has been taking part in nicely,” mentioned Williams. “She’s additionally a extremely superior individual off the courtroom. I really like seeing her within the locker room.
“Ideally it will be nice if we did not should play one another, as a result of I at all times need her to do tremendous nicely, so… It is wonderful, although.”
Williams may face Azarenka for a twenty fourth time within the quarter-finals, with an opportunity of revenge for her US Open last-four defeat final 12 months, however the Belarusian faces a difficult last-32 tie first up on Chatrier in opposition to Madison Keys.
Greek star Tsitsipas is well-fancied to achieve his maiden Grand Slam ultimate, with Rafael Nadal, Novak Djokovic and Roger Federer all within the different half of the draw, and along with his process made simpler by two-time runner-up Dominic Thiem’s shock first-round defeat.
The fifth seed cruised by his opening two matches in straight units in opposition to Jeremy Chardy and Pedro Martinez, however ought to face a far more durable check in Friday’s night time match in opposition to big-serving Isner.
The new and bouncy circumstances may play into the American thirty first seed’s fingers.
“I am positive he can serve nicely proper now,” admitted Tsitsipas, who has loved an excellent clay-court season, profitable the Monte Carlo Masters, the ATP occasion in Lyon and reaching the Barcelona Open ultimate, the place he misplaced to Nadal regardless of holding a match level.
The 22-year-old made the semi-finals final October earlier than shedding a five-set epic to Djokovic.
Medvedev had by no means received a French Open match till this week, however has discovered his type this time round and faces the USA’ Reilly Opelka on Court docket Suzanne Lenglen.
German sixth seed Zverev has not been at his finest to this point, however got here again from two units down within the first spherical in opposition to Oscar Otte earlier than edging Russian qualifier Roman Safiullin in three tight units.
He takes on Serbia’s Laslo Djere.
Elsewhere on Friday, ladies’s world quantity 4 Aryna Sabalenka, the highest-ranked participant left within the draw, performs Anastasia Pavlyuchenkova.
Former males’s world quantity 4 Kei Nishikori of Japan meets Swiss qualifier Henri Laaksonen after spending greater than eight hours on courtroom over the primary two rounds.